Hematological and Biochemical Reference Ranges for the Population with Sickle Cell Disease at Steady State in Tanzania

Hematological and biochemical reference values in sickle cell disease (SCD) are crucial for patient management the evaluation of interventions. This study was conducted at Muhimbili National Hospital (MNH) Dar es Salaam, Tanzania, to establish laboratory ranges among children adults with SCD steady state. Patients were grouped into five age groups according their sex. Aggregate functions used handle repeated measurements within individual level each group. A nonparametric approach smooth curves, a parametric determine normal ranges. Comparison between males females against general population documented. Data from 4422 patients collected 2004–2015 analyzed. The majority (35.41%) aged 5–11 years. There no significant differences (p ≥ 0.05) mean corpuscular hemoglobin concentration (MCHC), lymphocytes, basophils, direct bilirubin observed females. Significant < all selected parameters across except neutrophils MCHC adults, as well platelets alkaline phosphatase infants when estimates compared population. state different those varied sex age. established will be helpful monitoring progress SCD.